Herald Publications

Mechanism of Action and Preclinical Proof of Concept

• 3,3',5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent

• Src kinase integrates PI3K/Akt and MAPK/ERK1/2 pathways in T3-induced Na-K-ATPase activity in adult rat alveolar cells

• Triiodo-L-thyronine Rapidly Stimulates Alveolar Fluid Clearance in Normal and Hyperoxia-injured Lungs

Preclinical Safety

A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats — an Investigational Therapy for ARDS

Posters

• “Restoring lung & heart function with thyroid hormone,” for American Thoracic Society Respiratory Innovation Summit, 2026

• ”Development of Thyroid Hormone as a Treatment Therapy for Acute Respiratory Distress Syndrome,” 2022